Group

Form

Dosage

AUC₂₄ [µg/L*h]

k₀₅ [h]

R_max [µg/L]

k_s [h]

I_max [h]

C_K0.5 C_Ks [µg/L]

C_Imax [µg/L]

C_24h [µg/L]

1

Tablets

1

886^c

0.53

94.4^b

7.07

1.73

51.51^b

71.77^b

19.94^b

2

Pulverized tablet

1

2027^bc

0.60

227.7^b

7.60

1.89

121.89^b

181.04^b

40.54^ab

3

Pulverized tablet

2

3958^a

0.66

421.3^a

5.87

1.96

250.33^a

403.73^a

83.24^a

4

Powder

3

3720^ab

0.77

412.6^a

5.77

2.07

240.55^a

371.09^a

77.62^a

PSEM

442

0.15

46.9

1.49

0.30

26.28

40.60

11.93

p-value

<0.001

0.639

<0.001

0.717

0.864

<0.001

<0.001

0.003